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Palmatine

Catalog No. T5S0802 CAS 3486-67-7

Synonyms: Berbericinine, Burasaine

1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.

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Palmatine, CAS 3486-67-7

Pack Size	Availability	Price/USD
250 mg	In stock	$ 55.00
1 g	In stock	$ 82.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.49%

Purity: 97.11%

Purity: 96.28%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.
Targets&IC50	BChE:6.84 μM, AChE:0.51 μM
Source	Natural Products > Ranunculaceae > Coptis

Synonyms	Berbericinine, Burasaine
Molecular Weight	352.4
Formula	C21H22NO4
CAS No.	3486-67-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 64 mg/mL (181.61 mM)

References and Literature

1. Hambright H G, Batth I S, Xie J, et al. Palmatine inhibits growth and invasion in prostate cancer cell: Potential role forrpS6/NFκB/FLIP[J]. Mol Carcinog, 2015, 54(10):1227-1234.

Citations

1. Song Y, Xu C, Li X, et al. Palmatine Alleviates LPS-Induced Acute Lung Injury Via Interfering the Interaction of TAK1 and TAB1. Biochemical Pharmacology. 2022 Aug;202:115120. 2. Lin X, Chen D, Chu X, et al.Oxypalmatin regulates proliferation and apoptosis of breast cancer cells by inhibiting PI3K/AKT signaling and its efficacy against breast cancer organoids.Phytomedicine.2023: 154752. 3. Kim Y J, Kim T I, Lee A, et al.Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice.Pharmaceuticals.2023, 17(1): 6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Antiparasitic Natural Product Library Drug Repurposing Compound Library Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Gastroenteritis Natural Product Library Anti-Cancer Metabolism Compound Library

Related Products

Related compounds with same targets

Linrodostat Necrostatin-1 Palmatine chloride Coptisine chloride PF-06840003 Coptisine Navoximod IDO1-IN-23

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Palmatine 3486-67-7 Cell Cycle/Checkpoint Chromatin/Epigenetic Metabolism Neuroscience Indoleamine 2,3-Dioxygenase (IDO) Aurora Kinase AChE AChR IDO-1 fulminant hepatic failure Inhibitor West Nile virus colitis NS2B-NS3 Crohn’s disease ulcerative Virus Protease Berbericinine IBD Apoptosis Inflammatory bowel disease inhibit Burasaine memory-enhancing inhibitor

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