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Pantoprazole sodium

Catalog No. T6929 CAS 138786-67-1

Synonyms: Pantecta, SKF96022 sodium, SKF96022 (sodium), BY1023 (sodium), BY-1023 sodium, Pantoloc

Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.

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Pantoprazole sodium, CAS 138786-67-1

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
200 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.1%

Purity: 96.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production.
In vitro	pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein[2]. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells[3].
In vivo	After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells[4].
Cell Research	Pantoprazole sodium salts are resuspended in normal saline (0.85%) at 5 mg/ml immediately prior to use. When the SGC-7901 cells have reached 60–70% confluence, PPZ is added at a final concentration of 20 µg/ml, and the cells are cultured for additional experiments. For example, The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1×104/well, in 96-well plates and treated with PPZ for 24 h. (Only for Reference)

Synonyms	Pantecta, SKF96022 sodium, SKF96022 (sodium), BY1023 (sodium), BY-1023 sodium, Pantoloc
Molecular Weight	405.35
Formula	C16H14F2N3NaO4S
CAS No.	138786-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (185 mM)

H2O: 74 mg/mL (182.6 mM)

Ethanol: 75 mg/mL (185 mM)

References and Literature

1. Shen Y, et al. Oncol Lett. 2016, 11(1):717-722. 2. Shen Y, et al. Neoplasma. 2012, 59(2):142-149. 3. Y Wu, et al. Chinese Journal of Gastroenterology. 2010, 15(4):205-208. 4. Yeo M, et al. Clin Cancer Res. 2004, 10(24):8687-8696.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library EMA Approved Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library FDA-Approved Drug Library Glycometabolism Compound Library Ion Channel Inhibitor Library

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Keywords

Pantoprazole sodium 138786-67-1 Angiogenesis Apoptosis Autophagy Chromatin/Epigenetic Membrane transporter/Ion channel Others Proton pump HIF stability Pantecta inhibit anti-secretory SKF-96022 BY-1023 SKF96022 sodium H+/K+-ATPase BY1023 SKF96022 (sodium) exosome BY1023 (sodium) PPI orally BY 1023 MCF-7 Pantoprazole Proton Pump Doxorubicin Inhibitor SKF 96022 anti-ulcer SKF96022 BY-1023 sodium release A431 Pantoloc inhibitor

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