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Paritaprevir

Catalog No. T3226 CAS 1221573-85-8

Synonyms: ABT-450, Veruprevir

Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity against HCV genotype 1. Upon administration, paritaprevir reversibly binds to the active center and binding site of the HCV NS3/NS4A protease and prevents NS3/NS4A protease-mediated polyprotein maturation. This disrupts both the processing of viral proteins and the formation of the viral replication complex, which inhibits viral replication in HCV genotype 1-infected host cells. NS3, a serine protease, is essential for the proteolytic cleavage of multiple sites within the HCV polyprotein and plays a key role during HCV ribonucleic acid (RNA) replication. NS4A is an activating factor for NS3. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family, and infection is associated with the development of hepatocellular carcinoma (HCC).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Paritaprevir, CAS 1221573-85-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 58.00
25 mg	In stock	$ 90.00
50 mg	In stock	$ 156.00
100 mg	In stock	$ 282.00
200 mg	In stock	$ 508.00
1 mL * 10 mM (in DMSO)	In stock	$ 87.00

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Purity: 99.57%

Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Paritaprevir demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50 range, 0.09 to 19 nM), with an EC50 of 0.09 nM against GT4a[2].

Synonyms	ABT-450, Veruprevir
Molecular Weight	765.89
Formula	C40H43N7O7S
CAS No.	1221573-85-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (13.06 mM)

References and Literature

1. Smith, M., & Lim, A. (2015). Profile of paritaprevir/ritonavir/ombitasvir plus dasabuvir in the treatment of chronic hepatitis C virus genotype 1 infection. Drug Design, Development And Therapy, 6083. doi: 10.2147/dddt.s80226 2. Schnell G, et al. Hepatitis C Virus Genotype 4 Resistance and Subtype Demographic Characterization of Patients Treated with Ombitasvir plus Paritaprevir/ritonavir. Antimicrob Agents Chemother. 2015 Aug 17. pii: AAC.01229-15.

Related compound libraries

This product is contained In the following compound libraries：

Pediatric Drug Library Anti-Infection Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Anti-COVID-19 Compound Library Orally Active Compound Library Approved Drug Library Macrocyclic Compound Library Human Metabolite Library

Related Products

Related compounds with same targets

Danoprevir ACH-806 7-benzyl-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Letermovir Artemisinin Isatoribine BLT-1 Telaprevir

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Paritaprevir 1221573-85-8 Microbiology/Virology Proteases/Proteasome HCV Protease ABT-450 ABT 450 Veruprevir ABT450 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.