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Penfluridol

Catalog No. T1105 CAS 26864-56-2

Synonyms: R-16341, TLP-607

Penfluridol (TLP-607) is a highly potent antipsychotic.

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Penfluridol, CAS 26864-56-2

Pack Size	Availability	Price/USD
25 mg	In stock	$ 47.00
50 mg	In stock	$ 60.00
100 mg	In stock	$ 76.00
200 mg	In stock	$ 119.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.94%

Purity: 98.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Penfluridol (TLP-607) is a highly potent antipsychotic.
Targets&IC50	Dopamine receptor:1.6 μM(Ki)
In vivo	Penfluridol inhibits the binding of dopamine to its receptors with a Ki value of 1.6 μM. At a concentration of 10 μM, Penfluridol suppresses the contractile response of isolated rabbit thoracic aortic rings to NE and KCl, as well as the calcium influx stimulated by NE or KCl. Additionally, Penfluridol selectively inhibits the binding of [3H]Nitrendipine to rat cerebral cortex membranes and competitively antagonizes potassium-induced, calcium-dependent contractions in the rat vas deferens.

Synonyms	R-16341, TLP-607
Molecular Weight	523.97
Formula	C28H27ClF5NO
CAS No.	26864-56-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (177.5 mM)

DMSO: 93 mg/mL (177.5 mM)

References and Literature

1. Creese I, et al. Science, 1976 , 192(4238), 481-483. 2. Flaim SF, et al. Proc Natl Acad Sci U S A, 1985, 82(4), 1237-1241.

Citations

1. Su C, Cheng C, Rong Z, et al.Repurposing fluphenazine as an autophagy modulator for treating liver cancer.Heliyon.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library GPCR Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Obesity Compound Library Anti-Parkinson's Disease Compound Library Metabolism Compound Library Calcium Channel Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Penfluridol 26864-56-2 Autophagy GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel Dopamine Receptor Inhibitor Ca2+ channels R-16341 Ca channels R16341 R 16341 TLP607 inhibit TLP 607 TLP-607 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.