Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 105.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 463.00 | |
200 mg | In stock | $ 668.00 | |
500 mg | In stock | $ 987.00 |
Description | Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are not released from infected cells. Peramivir Trihydrate is a cyclopentane derivative with activity against influenza A and B viruses. |
Targets&IC50 | Neuraminidase:0.09 nM |
In vitro | When used in conjunction with favipiravir (20-40 mg/kg/day), peramivir (0.025-0.1 mg/kg/day) increases cell survival rates by 10-50%. At a dosage of 0.5 mg/kg/day, peramivir exhibits a protective effect against H1N1 in mice, covering about 30% of the virus. The combination of peramivir (1 mg/kg/day) with amantadine (5-10 mg/kg/day) results in weight losses of 1.69 and 0.69, respectively; however, for a sub-lethal influenza A (H3N2) virus model in mice, administering peramivir (3 mg/kg/day) alongside rimantadine (10-30 mg/kg/day) does not affect weight. At a higher concentration, peramivir (30 mg/kg) effectively extends the survival of mice infected with the systemically replicating H5N1 virus. |
Synonyms | RWJ-270201, S-021812, BCX-1812, RWJ 270201 trihydrate, BCX 1812 trihydrate |
Molecular Weight | 382.45 |
Formula | C15H28N4O4·3H2O |
CAS No. | 1041434-82-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 6.6 mg/mL (17.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Peramivir Trihydrate 1041434-82-5 Microbiology/Virology Influenza Virus RWJ-270201 RWJ-270201 Trihydrate inhibit BCX 1812 Trihydrate S021812 RWJ 270201 Trihydrate RWJ 270201 S-021812 BCX1812 BCX-1812 Inhibitor RWJ270201 RWJ 270201 trihydrate BCX 1812 trihydrate Peramivir RWJ270201 Trihydrate S 021812 BCX 1812 BCX1812 Trihydrate BCX-1812 Trihydrate inhibitor