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Philanthotoxin 74 dihydrochloride

Catalog No. T16524 CAS 1227301-51-0

Synonyms: PhTx-74 HCl, PhTx 74 dihydrochloride

Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Philanthotoxin 74 dihydrochloride Chemical Structure

Philanthotoxin 74 dihydrochloride, CAS 1227301-51-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 149.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 199.00

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Purity: 98.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
Targets&IC50	GluR1:296 nM
In vitro	Philanthotoxin 74 dihydrochloride inhibits the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3 in the micromolar concentration range, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 dihydrochloride (500 μM) fully inhibits GluA1/A2R receptors and produces 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74 dihydrochloride (100 and 500 μM) displays a pronounced channel block (> 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Philanthotoxin 74 dihydrochloride inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1].

Synonyms	PhTx-74 HCl, PhTx 74 dihydrochloride
Molecular Weight	507.54
Formula	C24H44Cl2N4O3
CAS No.	1227301-51-0

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (177.33 mM), Sonification is recommended.

H2O: 40 mg/mL (78.81 mM), Sonification is recommended.

References and Literature

1. Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8. 2. Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54.

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Keywords

Philanthotoxin 74 dihydrochloride 1227301-51-0 Membrane transporter/Ion channel Neuroscience iGluR GluR PhTx 74 Philanthotoxin 74 Dihydrochloride Philanthotoxin 74 PhTx-74 HCl PhTx 74 dihydrochloride PhTx 74 Dihydrochloride inhibitor inhibit

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