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Phosphoramidon Disodium

Catalog No. T6627 CAS 164204-38-0

Synonyms: Phosphoramidon Disodium Salt

Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.

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Phosphoramidon Disodium Chemical Structure

Phosphoramidon Disodium, CAS 164204-38-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool.
Targets&IC50	ACE:78 μM, ECE:3.5μM, NEP:0.034μM
In vitro	Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2]
In vivo	In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3]

Synonyms	Phosphoramidon Disodium Salt
Molecular Weight	588.48
Formula	C23H34N3Na2O10P
CAS No.	164204-38-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 169.9 mM

DMSO: 169.9 mM

References and Literature

1. Komiyama T, et al. Biochem Biophys Res Commun. 1975, 65(1), 352-357. 2. Pross M, et al. Surg Endosc. 2001, 15(8), 882-885. 3. Hanson LR, et al. J Mol Neurosci. 2011, 43(3), 424-427.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Phosphoramidon Disodium 164204-38-0 Endocrinology/Hormones Metabolism Others RAAS Neprilysin Inhibitor Phosphoramidon Disodium Salt NEP CD10 Angiotensin-converting Enzyme (ACE) Phosphoramidon Neutral endopeptidase Cluster of differentiation 10 inhibit inhibitor

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