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Picropodophyllotoxin

Catalog No. T3S0027   CAS 17434-18-3
Synonyms: AXL 1717, Picropodophyllin

Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Picropodophyllotoxin Chemical Structure
Picropodophyllotoxin, CAS 17434-18-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 32.00
5 mg In stock $ 74.00
10 mg In stock $ 96.00
25 mg In stock $ 189.00
50 mg In stock $ 309.00
100 mg In stock $ 466.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Purity: 99.57%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllotoxin (AXL 1717) specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells.
Source
Synonyms AXL 1717, Picropodophyllin
Molecular Weight 414.41
Formula C22H22O8
CAS No. 17434-18-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (108.59 mM)

TargetMolReferences and Literature

1. Rui-Hong F , Hai-Yan Y , Zhi-Qing M A , et al. Study on 6 insecticidal podophyllotoxin compounds from the berries of Sabina vulgaris Ant[J]. Journal of Northwest A & F University, 2007, 35(9):117-122.

Related compound libraries

This product is contained In the following compound libraries：
Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Miao medicine Compound Library Anti-Cancer Drug Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-COVID-19 Compound Library

Related Products

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BMS-754807 HNMPA KW-2450 free base Dusigitumab PD168393 MSDC 0160 ALK inhibitor 1 AZ7550

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Keywords

Picropodophyllotoxin 17434-18-3 Tyrosine Kinase/Adaptors IGF-1R AXL1717 AXL 1717 Picropodophyllin AXL-1717 inhibitor inhibit

 

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