Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 35.00 | |
100 mg | In stock | $ 50.00 | |
200 mg | In stock | $ 73.00 | |
500 mg | In stock | $ 117.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
Targets&IC50 | PPARγ (mouse):0.99 μM (EC50), PPARγ (human):0.93 μM (EC50) |
In vitro | In male obese rats, oral administration of Pioglitazone (0.3-3 mg/kg) over a period of 7 days resulted in a dose-dependent reduction of hyperglycemia, hyperlipidemia, and hyperinsulinemia. |
In vivo | Pioglitazone protects dopaminergic neurons from LPS-induced damage by inhibiting the expression of iNOS and the production of NO. It also suppresses the phosphorylation of p38 protein induced by lipopolysaccharides. |
Cell Research | In order to evaluate cell proliferation, HIT-T15 cells are seeded on 96-well plates (3×104 cells/well) and cultured for 5 days as described. Viable cells are determined using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay. To evaluate cell apoptosis and cell necrosis, HIT-T15 cells are plated on 6-well dishes (7×105 cells/well) for 5 days in standard conditions (CTR) or in the presence of AGEs (AGEs) with or without Pioglitazone (0.5 or 1 μM) or AG (1 mM). They are then processed to measure both the activity of caspase-3 and the activity of lactate dehydrogenase (LDH) (a stable cytosolic enzyme that is a marker of cell membrane damage and cell death due to necrosis) using Cytotox 96 Non Radioactive Cytotoxicity Assay[2]. |
Synonyms | U-72107E, AD 4833, U 72107A, Pioglitazone HCl |
Molecular Weight | 392.9 |
Formula | C19H20N2O3S·HCl |
CAS No. | 112529-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.8 mg/mL (25 mM)
You can also refer to dose conversion for different animals. More
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Pioglitazone hydrochloride 112529-15-4 Apoptosis DNA Damage/DNA Repair Metabolism Ferroptosis PPAR U-72107E AD 4833 Inhibitor Pioglitazone inhibit AD-4833 U 72107A Pioglitazone HCl Pioglitazone Hydrochloride Peroxisome proliferator-activated receptors AD4833 inhibitor