Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piperoxan hydrochloride (Benodaine hydrochloride) is an α2 adrenoceptor antagonist. Piperoxan (benodaine) is a drug which was the very first antihistamine to be discovered.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | Piperoxan hydrochloride (Benodaine hydrochloride) is an α2 adrenoceptor antagonist. Piperoxan (benodaine) is a drug which was the very first antihistamine to be discovered. |
In vitro | When superfusing the medulla with Piperoxan (50 μM; 5 min) and the pons with artificial cerebrospinal fluid (ACSF), three inactive preparations exhibit low-frequency rhythmic phrenic bursts (2-4 c/min), with the phrenic burst frequency in 12 active preparations significantly increasing to 163±12% of the previous average frequency in the final 3 minutes of Piperoxan application. In active preparations, the impact of norepinephrine (NA) applications (25 μM; 5 min) is assessed under conditions of superfusion with either ACSF (n=8) or α2 adrenoceptor antagonist Piperoxan (50 μM; PIP-ACSF; n=5). Both scenarios of NA application (NA-ACSF alone or combined with PIP-ACSF+NA) lead to a marked increase in phrenic burst frequency. Notably, inhibiting medullary α2 adrenoceptors with Piperoxan significantly enhances this effect: during NA application's fifth minute, phrenic burst frequency escalates to 171±11% with ACSF alone and 234±21% under PIP-ACSF, compared to the baseline control values. |
Synonyms | dl-Piperoxan hydrochloride, Benodaine hydrochloride |
Molecular Weight | 269.77 |
Formula | C14H20ClNO2 |
CAS No. | 135-87-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (185.34 mM)
You can also refer to dose conversion for different animals. More
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Piperoxan hydrochloride 135-87-5 GPCR/G Protein Neuroscience Adrenergic Receptor Piperoxan Beta Receptor inhibit Inhibitor dl-Piperoxan hydrochloride Piperoxan Hydrochloride Benodaine Hydrochloride dl-Piperoxan Hydrochloride Benodaine Benodaine hydrochloride inhibitor