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Pirinixic Acid

Catalog No. T2269 CAS 50892-23-4

Synonyms: Wy-14643, NSC 310038

Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated receptors (PPAR).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pirinixic Acid, CAS 50892-23-4

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
25 mg	In stock	$ 58.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 107.00
200 mg	In stock	$ 151.00
500 mg	In stock	$ 249.00
1 g	In stock	$ 369.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.92%

Purity: 99.83%

Purity: 99.35%

Purity: 98.27%

Biological Description

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Storage & Solubility Information

Description	Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated receptors (PPAR).
Targets&IC50	PPARα:1.5 μM(EC50)
In vitro	WY14643 significantly reduced visceral fat mass and total liver triglyceride content without increasing body weight. It enhanced systemic insulin sensitivity and improved insulin-mediated skeletal muscle glucose metabolism in both red (47%) and white (63%) muscle fibers, as well as in white adipose tissue (90%), while reducing muscle triglyceride and LCACoA accumulation. Administration of WY14643 (1 mg/kg i.v.) 30 minutes before left anterior descending artery occlusion led to a notable reduction in infarct size (~44%) in rats subjected to myocardial ischemia (25 minutes) followed by reperfusion (2 hours). In rats fed a high-fat diet, treatment with 3 mg/kg WY14643 lowered plasma glucose and triglyceride levels (-16% vs. untreated), leptin (-52%), muscle triglycerides (-34%), and overall long-chain acyl-coenzyme A (-41%) levels.
In vivo	WY14643 (250 μM) significantly reduces the expression levels of VCAM-1, lowering it to 52% of those in human endothelial cells stimulated by TNF-α. At a concentration of 10 μM, WY 14643 acts on aortic smooth muscle cells to almost completely inhibit the production of IL-6 and prostaglandin induced by IL-1, as well as the expression of cyclooxygenase-2, through the suppression of the NF-κB signaling pathway. Pre-treating endothelial cells with WY 14643 (10 μM) before TNF-α stimulation decreases U937 cell adhesion by 50%.
Kinase Assay	Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe.

Synonyms	Wy-14643, NSC 310038
Molecular Weight	323.8
Formula	C14H14ClN3O2S
CAS No.	50892-23-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.4 mg/mL (100 mM)

References and Literature

1. Issemann I, et al. Nature. 1990, 347(6294), 645-650. 2. Staels B, et al. Nature. 1998, 393(6687), 790-793. 3. Marx N, et al. Circulation, 1999, 99(24), 3125-3131. 4. Wayman NS, et al. FASEB J. 2002, 16(9), 1027-1040. 5. Ye JM, et al. Diabetes, 2001, 50(2), 411-417. 6. Pantazi E, et al. PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. Biomed Res Int. 2015;2015:894679. 7. Huang D, et al. PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway. J Mol Neurosci. 2016 Aug;59(4):544-53.

Citations

1. Ren Q, Xie X, Zhao C, et al. 2, 2′, 4, 4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation. Chemical Research in Toxicology. 2022

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Metabolism Disease Compound Library Lipid Metabolism Compound Library Target-Focused Phenotypic Screening Library Anti-Cardiovascular Disease Compound Library Glycometabolism Compound Library Stem Cell Differentiation Compound Library Anti-Diabetic Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pirinixic Acid 50892-23-4 DNA Damage/DNA Repair Metabolism PPAR Wy 14643 Wy-14643 Wy14643 NSC310038 NSC 310038 Peroxisome proliferator-activated receptors inhibit NSC-310038 Inhibitor inhibitor

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