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Piroxicam

Catalog No. T0758 CAS 36322-90-4

Synonyms: CP-16171

Piroxicam (CP-16171) is a non-specific COX inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Piroxicam, CAS 36322-90-4

Pack Size	Availability	Price/USD
500 mg	In stock	$ 45.00
1 g	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Piroxicam (CP-16171) is a non-specific COX inhibitor.
Targets&IC50	COX-2 (human monocyte):25 μM, COX-1:47 μM
In vitro	Piroxicam induces activation of extracellular signal-regulated kinase (ERK) in neurones and phosphorylation of heavy molecular weight neurofilaments, cytoskeletal substrates of ERK in rat spinal cord cultures. Piroxicam and NS-398 protect neurones against hypoxia/reperfusion in rat spinal cord cultures. [1]
In vivo	Piroxicam at doses higher than 0.04%, strongly inhibits the development of GST-P-positive and neoplastic nodules as well as fibrosis, cirrhosis and formation of 8-hydroxydeoxyguanosine (8-OHdG) adducts in rats. [2] Piroxicam increases the expression of all three MHC antigens compared to either control or azoxymethane (AOM)-treated rats. Piroxicam up-regulates colonic MHC antigen expression in the AOM model of colonic carcinogenesis. [3] Piroxicam combined with Cisplatin has antitumor activity against oral malignant melanoma (OMM) and oral squamous cell carcinoma (SCC) in rats. [4] Piroxicam inhibits prostaglandin synthesis through cyclooxygenase blockade in dog, and Piroxicam does not have any direct cytotoxic effects in vitro. [5] Piroxicam also binds strongly to plasma proteins and Piroxicam could stop Ochratoxin A (OTA) -binding and transport into target organs, thereby preventing its nephrotoxicity in rats. Piroxicam prevents the enzymuria induced by OTA and increases renal elimination of OTA in rats. [6]

Synonyms	CP-16171
Molecular Weight	331.35
Formula	C15H13N3O4S
CAS No.	36322-90-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL (3.01 mM)

DMSO: 61 mg/mL (184.1 mM)

References and Literature

1. Vartiainen N, et al. J Neurochem,2001, 76(2), 480-489. 2. Denda A, et al. Carcinogenesis,1997, 18(10), 1921-1930. 3. Rigas B, et al. Immunology,1994, 83(2), 319-323. 4. Boria PA, et al. J Am Vet Med Assoc,2004, 224(3), 388-394. 5. Schmidt BR, et al. J Am Vet Med Assoc,2001, 218(11), 1783-1786. 6. Silva J, et al. Synergistic Effect of Carboplatin and Piroxicam on Two Bladder Cancer Cell Lines. Anticancer Res. 2017 Apr;37(4):1737-1745.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Mitochondria-Targeted Compound Library Human Metabolite Library Anti-Pancreatic Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library

Related Products

Related compounds with same targets

Tetrahydroamentoflavone Diclofenac diethylamine COX-2-IN-34 N-trans-Feruloyltyramine Firocoxib Ginsenoside Rg5 Pelubiprofen Lornoxicam

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Piroxicam 36322-90-4 Immunology/Inflammation Neuroscience COX Cyclooxygenase CP 16171 CP-16171 inhibit CP16171 Inhibitor inhibitor

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