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Plantainoside D

Catalog No. T5796 CAS 147331-98-4

Synonyms: Isoplantamajoside

Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.

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Plantainoside D, CAS 147331-98-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 298.00
10 mg	In stock	$ 452.00
25 mg	In stock	$ 745.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 395.00

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Purity: 99.39%

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Description	Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it also shows inhibitory activity against PKCalpha with the IC50 value14.8microM.
Targets&IC50	ACE:2.17 mM , PKC:14.8microM
In vitro	Plantago asiatica L. and its major constituents(such as Plantainoside D) have ACE inhibitory activity in vitro. The identified compounds contribute to the angiotensin-converting enzyme-inhibitory activity of the extract[1].In vitro, Adriamycin(ADR) caused dose-dependent toxicity in H9c2 cardiac muscle cells. Pre-treatment of the cardiac muscle cells with Plantainoside D(PD) significantly reduced ADR-induced apoptosis of cardiac muscle cells. PD inhibited the ROS produced by ADR in the cardiac muscle cells. As well, PD increased GSH(glutathione), compared with ADR. In response to ADR, NF-kappaB was activated in H9c2 cells. However the treatment of PD reduced the activation of NF-kappaB.The NF-kappaB inhibitor, PDTC, inhibited the cytotoxic effect on ADR-induced apoptosis in cardiac muscle cells. IkappaBalpha-dominant negative plasmid-overexpression abrogated ADR-induced apoptosis in H9c2 cardiac muscle cells[2].
Kinase Assay	Ethanolic extract of the seeds of Plantago asiatica L. showed significant inhibitory activity of angiotensin-converting enzyme (ACE) determined by monitoring the transformation from a substrate hippuryl-histidyl-leucine (HHL) to the product hippuric acid (HA) in vitro using an UPLC-MS method. The bioguided fractionation of the extract resulted in the isolation of four ACE inhibitory active phenylpropanoid glycosides acteoside, isoacteoside, Plantainoside D, and plantamajoside with IC(50) values of 2.69 mM, 2.46 mM, 2.17 mM, and 2.47 mM, respectively. Their structures were elucidated through the analysis of NMR, UV, IR and MS data[1].
Source	Natural Products > Plantaginaceae > Plantago

Synonyms	Isoplantamajoside
Molecular Weight	640.59
Formula	C29H36O16
CAS No.	147331-98-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (15.6 mM), Sonification is recommended.

DMSO: 10 mM

References and Literature

1. Geng F , Yang L , Chou G , et al. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L.[J]. Phytotherapy Research, 2010, 24(7):0-0. 2. Kim D S , Woo E R , Chae S W , et al. Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-κB activation[J]. Life Sciences, 2007, 80(4):0-323.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Membrane Protein-targeted Compound Library TGF-beta/Smad Compound Library Oxidation-Reduction Compound Library Covalent Natural Product Library Cytoskeletal Signaling Pathway Compound Library Natural Product Library Tibetan medicine Compound Library Bioactive Compounds Library Max

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Keywords

Plantainoside D 147331-98-4 Chromatin/Epigenetic Cytoskeletal Signaling Endocrinology/Hormones RAAS PKC I kappa B kinase Inhibitor IKK Isoplantamajoside Angiotensin-converting Enzyme (ACE) inhibit IκB kinase inhibitor

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