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Polygalasaponin F

Catalog No. T3826   CAS 882664-74-6

Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.

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Polygalasaponin F Chemical Structure
Polygalasaponin F, CAS 882664-74-6
Pack Size Availability Price/USD Quantity
20 mg In stock $ 100.00
1 mL * 10 mM (in DMSO) In stock $ 120.00
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Purity: 99.75%
Purity: 99.15%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.
Source
Molecular Weight 1091.24
Formula C53H86O23
CAS No. 882664-74-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 91.6 mM

TargetMolReferences and Literature

1. Zhou W,et al. Quantification of polygalasaponin F in rat plasma using liquid chromatography-tandem mass spectrometry and its pharmacokinetics application. Biomed Chromatogr. 2015 Sep;29(9):1388-92. 2. Wei WWei ,et al. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation. J Asian Nat Prod Res. 2014;16(8):865-75.

TargetMolCitations

1. Chen Y, Li H, Yang Y, et al.Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia/reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway.Journal of Neuroimmunology.2024: 578281.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Angiogenesis related Compound Library Kinase Inhibitor Library Oxidation-Reduction Compound Library Bioactive Compounds Library Max HIF-1 Signaling Pathway Compound Library Glutamine Metabolism Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

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Keywords

Polygalasaponin F 882664-74-6 Cytoskeletal Signaling Immunology/Inflammation NF-Κb PI3K/Akt/mTOR signaling TLR PI3K Akt NF-κB Phosphoinositide 3-kinase Nuclear factor-kappaB inhibit Protein kinase B PKB Nuclear factor-κB Toll-like Receptor (TLR) Inhibitor inhibitor

 

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