Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 mg | In stock | $ 100.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 120.00 |
Description | Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway. |
Source |
Molecular Weight | 1091.24 |
Formula | C53H86O23 |
CAS No. | 882664-74-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91.6 mM
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Polygalasaponin F 882664-74-6 Cytoskeletal Signaling Immunology/Inflammation NF-Κb PI3K/Akt/mTOR signaling TLR PI3K Akt NF-κB Phosphoinositide 3-kinase Nuclear factor-kappaB inhibit Protein kinase B PKB Nuclear factor-κB Toll-like Receptor (TLR) Inhibitor inhibitor