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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Polyporenic acid C shows inhibitory activity against human collagenase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 147.00 | |
5 mg | In stock | $ 378.00 | |
10 mg | In stock | $ 558.00 | |
25 mg | In stock | $ 886.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,580.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 429.00 |
Description | Polyporenic acid C shows inhibitory activity against human collagenase. |
In vitro | Polyporenic acid C (PPAC) significantly reduced cell proliferation via induction of apoptosis as evidenced by sub-G1 analysis, annexin V-FITC staining, and increase in cleavage of procaspase-8, -3, and poly(ADP-ribose)-polymerase (PARP). However, unlike our previously reported lanostane-type triterpenoid, pachymic acid, treatment of cells with PPAC was not accompanied by disruption of mitochondrial membrane potential and increase in cleavage of procaspase-9. Further, PPC-induced apoptosis was inhibited by caspase-8 and pan-caspase inhibitors but not by a caspase-9 inhibitor. |
Source |
Molecular Weight | 482.69 |
Formula | C31H46O4 |
CAS No. | 465-18-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (124.3 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Polyporenic acid C 465-18-9 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair PI3K/Akt/mTOR signaling Proteases/Proteasome Caspase PI3K PARP cell inhibit Inhibitor lung cancer NSCLC inhibitor