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Porcn-IN-1

Catalog No. T4438 CAS 2036044-77-4

Synonyms: Porcupine-IN-1

Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Porcn-IN-1, CAS 2036044-77-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 346.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Targets&IC50	Porcupine:0.5 Nm
In vitro	Porcupine, an enzyme, facilitates the attachment of palmitoleate to a serine residue within Wnt proteins, essential for their secretion. Porcupine-IN-1 exhibits potency comparable to the clinical compound LGK974 in a cell-based STF reporter gene assay and effectively inhibits the secretion of Wnt3A, thereby confirming its role as a porcupine inhibitor[1].
In vivo	Porcupine-IN-1 exhibits moderate metabolic clearance in human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg), while demonstrating high clearance rates in mouse liver microsomes (109 mL/min/kg)[1].
Cell Research	HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium[1].

Synonyms	Porcupine-IN-1
Molecular Weight	410.44
Formula	C25H19FN4O
CAS No.	2036044-77-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (243.64 mM)

References and Literature

1. Xu Z, Xu X, O’Laoi R, et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’amide scaffold[J]. Bioorganic & medicinal chemistry, 2016, 24(22): 5861-5872.

Citations

1. Wu W, Xu H, Liao C, et al. Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination. Cellular Oncology. 2022: 1-15 2. Yue X, Liu T, Wang X, et al.Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1–BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.Acta Pharmaceutica Sinica B.2023

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Anti-Aging Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

ETC-159 GNF-6231 IWP L6 IWP-2 Wnt-C59 IWP-O1 LGK974

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Porcn-IN-1 2036044-77-4 Stem Cells Porcupine inhibit PorcnIN1 Inhibitor Porcupine-IN-1 Porcn IN 1 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.