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Catalog No. T0851   CAS 145-13-1
Synonyms: 3β-Hydroxy-5-pregnen-20-one, Arthenolone

Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.

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Pregnenolone, CAS 145-13-1
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pregnenolone is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.
In vitro Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. [1] Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. [2] Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. [3]
In vivo Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. [4] Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. [5] Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. [6]
Synonyms 3β-Hydroxy-5-pregnen-20-one, Arthenolone
Molecular Weight 316.4776
Formula C21H32O2
CAS No. 145-13-1


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 21 mg/mL (66.4 mM)

DMSO: 21 mg/mL (66.4 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Murakami K, et al. Proc Natl Acad Sci U S A, 2000, 97(7), 3579-3584. 2. Hsu HJ, et al. Nature,2006, 439(7075), 480-483. 3. Gursoy E, et al. Neurochem Res,2001, 26(1), 15-21. 4. Grigoryev DN, et al. J Steroid Biochem Mol Biol, 2000, 75(1), 1-10. 5. García-Estrada J, et al. Int J Dev Neurosci. 1999 Apr;17(2):145-51.

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Pregnenolone 145-13-1 Autophagy GPCR/G Protein Membrane transporter/Ion channel Metabolism Neuroscience Cannabinoid Receptor Endogenous Metabolite AChR TRP/TRPV Channel 3β-Hydroxy-5-pregnen-20-one Transient receptor potential channels inhibit TRP Channel Inhibitor Arthenolone inhibitor