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Procyanidin B1

Catalog No. TQ0205 CAS 20315-25-7

Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.

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Procyanidin B1, CAS 20315-25-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 489.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 969.00
1 mL * 10 mM (in DMSO)	In stock	$ 233.00

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Purity: 99.13%

Purity: 98.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
In vitro	Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells [1]. Procyanidin B1 (50-100 μM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at concentrations of 30, 50, and 100 μM and caspase-9 at concentrations of 10, 30, 50, and 100 μM [2]. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα [3].
Cell Research	To investigate the cytotoxic effect of Procyanidin B1, the viability of THP1 cells is assessed using the CCK8 assay. THP1 cells are treated with Procyanidin B1 for 18 h, and 10 μL of CCK8 solution is then added to each well and the cultures are incubated for 4 h at 37°C. The optical density (OD) at 450 nm is measured using an ELx808 Absorbance Microplate Reader. The Procyanidin B1 concentration tested ranges from 50 to 200 μg/mL. Each sample is tested in triplicate [1].
Source	Natural Products > Vitaceae > Vitis

Molecular Weight	578.52
Formula	C30H26O12
CAS No.	20315-25-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (39.76 mM), Sonication is recommended.

References and Literature

1. Xing J, et al. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling. Mol Cell Biochem. 2015 Sep;407(1-2):89-95. 2. Kanno H, et al. Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid β oligomer-induced neuronal death. J Ethnopharmacol. 2015 Jan 15;159:122-8. 3. Shimada T, et al. Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. Eur J Pharmacol. 2012 Feb 29;677(1-3):147-53.

Related compound libraries

This product is contained In the following compound libraries：

Miao medicine Compound Library Membrane Protein-targeted Compound Library Immuno-Oncology Compound Library Natural Product Library Chinese Pharmacopoeia Natural Product Library Food as Medicine Compound Library Traditional Mongolian Medicine Compound Library Human Metabolite Library Bioactive Compounds Library Max Selected Plant-Sourced Compound Library

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Keywords

Procyanidin B1 20315-25-7 Immunology/Inflammation TLR Toll-like Receptor (TLR) Inhibitor Procyanidin B-1 inhibit Procyanidin B 1 inhibitor

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