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Procyanidin B2

Catalog No. T6S1367 CAS 29106-49-8

Synonyms: Proanthocyanidin B2

Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway.

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Procyanidin B2, CAS 29106-49-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 146.00
20 mg	In stock	$ 350.00
1 mL * 10 mM (in DMSO)	In stock	$ 161.00

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Purity: 99.21%

Purity: 97.69%

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Description	Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway.
In vitro	Procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions[1].
In vivo	Procyanidin B2 from cinnamon inhibited AGE accumulation in diabetic rat kidney and ameliorated AGE mediated pathogenesis of DN[2].
Animal Research	Streptozotocin-induced diabetic rats were fed with either 3% cinnamon or 0.002% Procyanidin B2(PCB2)-fraction in diet for 12weeks. Biochemical analysis of blood and urine was performed at the end of experiment. Evaluation of glomerular markers that serve as indicators of renal function was done by immunohistochemistry, immunoblotting and qRT-PCR. Supplementation of diabetic rats with cinnamon and PCB2-fraction prevented glycation mediated RBC-IgG cross-links and HbA1c accumulation in diabetes rats. Cinnamon and PCB2-fraction also inhibited the accumulation of N-carboxy methyl lysine (CML), a prominent AGE in diabetic kidney[2].
Source	Natural Products > Vitaceae > Vitis

Synonyms	Proanthocyanidin B2
Molecular Weight	578.52
Formula	C30H26O12
CAS No.	29106-49-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (86.43 mM)

References and Literature

1. Sakano K , Mizutani M , Murata M , et al. Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage[J]. Free Radical Biology & Medicine, 2005, 39(8):1041-1049. 2. Muthenna P , Raghu G , Kumar P A , et al. Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats[J]. Chemico-Biological Interactions, 2014, 222:68-76.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Miao medicine Compound Library Tobacco Monomer Library Human Metabolite Library Traditional Chinese Medicine Monomer Library Natural Product Library Mitochondria-Targeted Compound Library Anti-Liver Cancer Compound Library NF-κB Signaling Compound Library Cuproptosis Compound Library

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Keywords

Procyanidin B2 29106-49-8 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species NOD inhibit Proanthocyanidin B 2 Procyanidin B 2 Inhibitor Proanthocyanidin B-2 Proanthocyanidin B2 Procyanidin B-2 inhibitor

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