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Prostaglandin E1

Catalog No. T1626 CAS 745-65-3

Synonyms: PGE1, Alprostadil

Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.

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Prostaglandin E1, CAS 745-65-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 39.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 96.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 382.00
100 mg	In stock	$ 553.00
200 mg	In stock	$ 748.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 100%

Purity: 99.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	PGE1, Alprostadil
Molecular Weight	354.48
Formula	C20H34O5
CAS No.	745-65-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 17.7 mg/mL (50 mM)

References and Literature

1. Dijkstra BG, et al. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2622-6.

Citations

1. Zhang T, Liu L, Huang X, et al.Application of microfluidic chip technology to study the inhibitory effect of tetramethylpyrazine on platelet aggregation, activation, and phosphatidylserine exposure mediated by pathological high shear rate.Blood Coagulation & Fibrinolysis.2023, 34(1): 47-60. 2. Zhang T, Liu L, Huang X, et al.The rapid change of shear rate gradient is beneficial to platelet activation.Platelets.2024, 35(1): 2288679.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Human Endogenous Metabolite Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Prostaglandin E1 745-65-3 GPCR/G Protein Immunology/Inflammation Metabolism Endogenous Metabolite Prostaglandin Receptor EP4 vasodilation EP3 PGE-1 PGE1 prostanoid Prostaglandin E-1 inhibit EP1 Prostaglandin E 1 aggregation PGE 1 Alprostadil Inhibitor vasodilator EP2 platelet inhibitor

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