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Pz-1

Catalog No. T12598 CAS 1800505-64-9

Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.

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Pz-1, CAS 1800505-64-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 563.00
100 mg	In stock	$ 812.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 99.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
Targets&IC50	RET/VEGFR2:< 1 nM
In vitro	Pz-1(1.0 nM) strongly inhibited phosphorylation of all tested RET oncoproteins in cell-based assays with IC50s of less than 1 nM for both VEGFR2 and RET wild type kinases[1].
In vivo	Pz-1 (1.0 mg/kg) abrogated the formation of tumors induced by RET-mutant fibroblasts and blocked the phosphorylation of both RET and VEGFR2 in tumor tissue. Pz-1 featured no detectable toxicity at concentrations of up to 100.0 mg/kg[1].

Molecular Weight	454.52
Formula	C26H26N6O2
CAS No.	1800505-64-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (99.01 mM), Sonification is recommended.

References and Literature

1. Frett B, et al. Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology. Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8717-21.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Ovarian Cancer Compound Library Anti-Cardiovascular Disease Compound Library Anti-Breast Cancer Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library

Related Products

Related compounds with same targets

Capillarisin Dovitinib OSI-930 T-1-MCPAB Ribociclib MAZ51 Acrizanib hCA/VEGFR-2-IN-2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pz-1 1800505-64-9 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors VEGFR c-RET Pz 1 Vascular endothelial growth factor receptor inhibit RET Inhibitor Pz1 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.