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GPCR/G Protein GTPase QS 11

QS 11

Catalog No. T4022   CAS 944328-88-5
Purity 100.00% Datasheet

QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

QS 11, CAS 944328-88-5
Pack Size Availability Price/USD Quantity
2 mg In stock 56.00
5 mg In stock 100.00
10 mg In stock 178.00
25 mg In stock 404.00
50 mg In stock 731.00
100 mg Inquiry 1185.00
1 mL * 10 mM (in DMSO) In stock 135.00
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Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
Targets&IC50 ARFGAP1,  
Appearance solid
Molecular Weight 567.70
Formula C36H33N5O2
CAS No. 944328-88-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 100 mM

Ethanol: 100 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Emre N., et al. A chemical approach to stem cell biology. Curr Opin Chem Biol. 2007 Jun;11(3):252-8. 2. Zhang Q., et al. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7444-8.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Anti-cancer Compound Library GPCR Compound Library

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CCG 50014 CCG 50014 CCG 50014 CCG 50014 QS 11 Gancaonin I CCG 203769 RBC8

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