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Quassin

Catalog No. TN2120   CAS 76-78-8

Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.

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Quassin Chemical Structure
Quassin, CAS 76-78-8
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.
Targets&IC50 P. falciparum:0.15 μM (IC50)
In vitro An HPLC method was employed for purification of the biologically active Quassinoids; Quassin (Q) and neo-Quassin (NQ), further characterized by MALDI-TOF analyses. Purified Q, NQ and the crude bark extract (S1) along with artesunate (AS) were studied for their in vitro anti-plasmodial activity. The in vivo toxicity studies at intraperitoneal doses with higher concentrations of the crude bark extract (S1) in Balb/C mice ruled out the apprehension of toxicity. Interaction studies between the test compounds among themselves (Q+NQ) and individually with artesunate (AS+Q, AS+NQ), were carried out in vitro at four ratios (1:5, 1:2, 2:1 and 5:1) on chloroquine sensitive (MRC-pf-20) and resistant (MRC-pf-303) strains of Plasmodium falciparum. The crude bark extracts of Q. amara exhibited higher P. falciparum inhibitory activity (IC(50)=0.0025 microg/ml) as compared to that of the isolated compounds, Quassin (IC(50)=0.06 microg/ml, 0.15 microM), neo-Quassin (IC(50)=0.04 microg/ml, 0.1 microM) and also to the positive control, artesunate (IC(50)=0.02 microg/ml, 0.05 microM)[1]
Source
Molecular Weight 388.45
Formula C22H28O6
CAS No. 76-78-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin.Exp Parasitol. 2010 Apr;124(4):421-7.

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Keywords

Quassin 76-78-8 Microbiology/Virology Others Antifection inhibitor inhibit

 

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