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RK-9123016

Catalog No. T28543 CAS 955900-27-3

Synonyms: RK9123016, RK 9123016

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.

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RK-9123016, CAS 955900-27-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 75.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 192.00
100 mg	In stock	$ 287.00
200 mg	In stock	$ 431.00
1 mL * 10 mM (in DMSO)	In stock	$ 67.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
In vitro	RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 µM).

Synonyms	RK9123016, RK 9123016
Molecular Weight	374.42
Formula	C16H18N6O3S
CAS No.	955900-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.75 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Shah AA, Ito A, Nakata A, Yoshida M. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. Biol Pharm Bull. 2016;39(10):1739-1742. PubMed PMID: 27725455.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Epigenetics Compound Library Anti-Cancer Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Bioactive Compound Library

Related Products

Related compounds with same targets

AK-1 Tenovin-6 Ginkgolide C UBCS039 SIRT1 activator 1 Thiomyristoyl AK-7 Selisistat

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Keywords

RK-9123016 955900-27-3 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin RK9123016 RK 9123016 inhibitor inhibit

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