Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 279.00 |
Description | RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. |
Targets&IC50 | RORγ:63.8 nM |
In vitro | RORγt inverse agonist 13 (Compound 3i) shows an inhibition of 76% at 0.3?μM in Th17 cell differentiation assay[1]. |
In vivo | RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1]. |
Molecular Weight | 513.29 |
Formula | C23H17Cl2F3N2O4 |
CAS No. | 2170477-75-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (19.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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