Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ). |
Targets&IC50 | ACAT (rat):25 nM , ACAT (rabbit):44 nM |
In vitro | RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D. |
In vivo | In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels. |
Molecular Weight | 416.58 |
Formula | C25H28N4S |
CAS No. | 136609-26-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (300.06 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RP 70676 136609-26-2 Metabolism Acyltransferase Diacylglycerol acyltransferase mono- acylglycerol acyltransferase acyl-CoA:cholesterol acyltransferase inhibit Inhibitor Diglyceride acyltransferase RP-70676 RP70676 inhibitor