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RU 58841

Catalog No. T2236 CAS 154992-24-2

Synonyms: RU58841, PSK-3841, HMR-3841

RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen; RU 58841(PSK-3841) has a significant effect on hair regrowth.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RU 58841, CAS 154992-24-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 63.00
25 mg	In stock	$ 108.00
50 mg	In stock	$ 143.00
100 mg	In stock	$ 207.00
500 mg	In stock	$ 515.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.77%

Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen; RU 58841(PSK-3841) has a significant effect on hair regrowth.

Kinase Assay

In vitro Protein Kinase, PI3K, and mTOR Assays: PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.

Synonyms	RU58841, PSK-3841, HMR-3841
Molecular Weight	369.34
Formula	C17H18F3N3O3
CAS No.	154992-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 66 mg/mL(178.7 mM)

References and Literature

1. Battmann T, et al. J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60.2. Münster U, et al. Pharmazie. 2005 Jan;60(1):8-12.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library ReFRAME Related Library Clinical Compound Library Bioactive Compounds Library Max Nuclear Receptor Compound Library Endocrinology-Hormone Compound Library

Related Products

Related compounds with same targets

CLP-3094 Bifluranol Atraric acid 2,2,5,7,8-Pentamethyl-6-Chromanol BMS-564929 Rezvilutamide Androgen receptor degrader-1 Adrenosterone

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RU 58841 154992-24-2 Endocrinology/Hormones Androgen Receptor HMR3841 Inhibitor RU58841 PSK 3841 RU-58841 PSK3841 inhibit PSK-3841 HMR-3841 HMR 3841 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.