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Rabeprazole sodium

Catalog No. T1651   CAS 117976-90-6
Synonyms: Dexrabeprazole Sodium, LY307640 sodium, Habeprazole Sodium, Rebeprazole sodium, Aciphex Sodium

Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.

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Rabeprazole sodium Chemical Structure
Rabeprazole sodium, CAS 117976-90-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 30.00
10 mg In stock $ 47.00
25 mg In stock $ 73.00
50 mg In stock $ 96.00
100 mg In stock $ 142.00
200 mg In stock $ 198.00
500 mg In stock $ 353.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.36%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.
Targets&IC50 UNH:0.3 μM (IC50)
In vitro Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway[2].
In vivo Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease[1].
Cell Research Rabeprazole is administrated to three gastric cancer cell lines, KATO III, MKN-28 and MKN-45, at a dosage of 0.2 mM for 16 h. The viability of these cells is determined by a trypan blue exclusion assay.(Only for Reference)
Synonyms Dexrabeprazole Sodium, LY307640 sodium, Habeprazole Sodium, Rebeprazole sodium, Aciphex Sodium
Molecular Weight 381.42
Formula C18H20N3NaO3S
CAS No. 117976-90-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 71 mg/mL (186.1 mM)

H2O: 1.34mg/mL(3.5mM), Sonification is recommended

Ethanol: 71 mg/mL (186.1 mM)

TargetMolReferences and Literature

1. Yamasaki Y, et al. Biomed Rep. 2016, 5(1):118-124. 2. Gu M, et al. Oncol Lett. 2014, 8(4):1739-1744.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library Apoptosis Compound Library Inhibitor Library Anti-Cancer Compound Library Orally Active Compound Library Drug Repurposing Compound Library

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Keywords

Rabeprazole sodium 117976-90-6 Apoptosis Membrane transporter/Ion channel Proton pump ATPase Dexrabeprazole Sodium LY 307640 ulcerations gastric LY307640 sodium LY307640 UNH Habeprazole Sodium PPI inhibit pump proton Proton Pump reflux uridine Rebeprazole sodium Rabeprazole LY-307640 nucleoside ribohydrolase Inhibitor gastroesophageal Aciphex Sodium inhibitor

 

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