Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 166.00 | |
25 mg | In stock | $ 279.00 | |
50 mg | In stock | $ 419.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 127.00 |
Description | Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2. |
Targets&IC50 | PLA2:2.6 μM |
In vitro | In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1]. |
In vivo | In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model |
Source |
Synonyms | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone, 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione |
Molecular Weight | 322.44 |
Formula | C19H30O4 |
CAS No. | 573-40-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (201.59 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rapanone 573-40-0 Apoptosis Metabolism Microbiology/Virology Parasite Phospholipase Antibacterial antioxidant anti-inflammatory Bacterial inhibit anti-tumor antiparasiti synovial PLA2 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione benzoquinone antibacterial Inhibitor inhibitor