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Rapastinel Trifluoroacetate

Catalog No. T5819 CAS 1435786-04-1

Synonyms: Thr-Pro-Pro-Thr-NH2 Trifluoroacetate, GLYX-13 Trifluoroacetate

Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.

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Rapastinel Trifluoroacetate Chemical Structure

Rapastinel Trifluoroacetate, CAS 1435786-04-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
5 mg	In stock	$ 172.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 537.00
50 mg	In stock	$ 768.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 2,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 196.00

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Purity: 99.96%

Purity: 99.37%

Biological Description

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Storage & Solubility Information

Description	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) is an NMDA receptor modulator with glycine-site partial agonist properties.
In vivo	Rapastinel Trifluoroacetate, a tetrapeptide (Thr-Pro-Pro-Thr-amide), has been reported to have fast acting antidepressant properties in man based upon its N-methyl-D-aspartate receptor (NMDAR) glycine site functional partial agonism.
Animal Research	C57BL/6J mice given a single dose or subchronic ketamine (30 mg/kg.i.p.) showed acute or persistent deficits in NOR, respectively.?Acute i.v. rapastinel (1.0 mg/kg), did not induce NOR deficit.?Pre-treatment with Rapastinel Trifluoroacetate?significantly prevented acute ketamine-induced NOR deficit.?Rapastinel Trifluoroacetate?(1.0 mg/kg, but not 0.3 mg/kg, iv) significantly reversed both subchronic ketamine- and subchronic PCP-induced NOR deficits.?Rapastinel Trifluoroacetate?also potentiated the atypical antipsychotic drug with antidepressant properties, lurasidone, to restore NOR in subchronic ketamine-treated mice.?Unlike ketamine,Rapastinel Trifluoroacetate?does not induce a declarative memory deficit in mice, and can prevent or reverse the ketamine-induced NOR deficit.?Further study is required to determine if these differences translate during clinical use of ketamine and rapastinel as fast acting antidepressant drugs and if rapastinel could have non-ionotropic effects as an add-on therapy with antipsychotic/antidepressant medications.

Synonyms	Thr-Pro-Pro-Thr-NH2 Trifluoroacetate, GLYX-13 Trifluoroacetate
Molecular Weight	527.49
Formula	C20H32F3N5O8
CAS No.	1435786-04-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (236.97 mM)

References and Literature

1. Rajagopal L , Burgdorf J S , Moskal J R , et al. GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice.[J]. Behavioural Brain Research, 2016, 299:105-110.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Neurotransmitter Receptor Compound Library Antidepressant Compound Library Bioactive Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Anti-Alzheimer's Disease Compound Library

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Keywords

Rapastinel Trifluoroacetate 1435786-04-1 Membrane transporter/Ion channel Neuroscience NMDAR iGluR GLYX 13 inhibit GLYX13 GLYX-13 Inhibitor Rapastinel GLYX13 Trifluoroacetate Thr-Pro-Pro-Thr-NH2 Trifluoroacetate Ionotropic glutamate receptors GLYX-13 Trifluoroacetate GLYX 13 Trifluoroacetate inhibitor

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