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Rasarfin

Catalog No. T9407 CAS 674359-73-0

Rasarfin inhibits Ras and ARF6.

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Rasarfin, CAS 674359-73-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 56.00
2 mg	In stock	$ 79.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 359.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 852.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 98.58%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Rasarfin inhibits Ras and ARF6.

In vitro

Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72?h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10?μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10?μM of Rasarfin treatment[1].

Molecular Weight	425.91
Formula	C23H24ClN3O3
CAS No.	674359-73-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (140.87 mM)

References and Literature

1. Jenna Giubilaro, et al. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nat Commun. 2021 Aug 3;12(1):4688.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Kinase Inhibitor Library Inhibitor Library HIF-1 Signaling Pathway Compound Library Anti-Colorectal Cancer Compound Library Anti-Obesity Compound Library Anti-Cancer Metabolism Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

KRAS G12C inhibitor 15 CID-1067700 Garsorasib Sotorasib MRTX1133 BI-2852 Kobe0065 FTI-277 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rasarfin 674359-73-0 GPCR/G Protein MAPK Others Ras breast cancer Inhibitor TNBC negative GPCR inhibit internalization triple inhibitor

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