Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 45.00 | |
1 g | In stock | $ 54.00 | |
5 g | In stock | $ 153.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. |
Synonyms | Proamipide, OPC12759 |
Molecular Weight | 370.79 |
Formula | C19H15ClN2O4 |
CAS No. | 90098-04-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.1 mM)
You can also refer to dose conversion for different animals. More
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Rebamipide 90098-04-7 GPCR/G Protein Immunology/Inflammation Neuroscience oxidation-reduction Free radical scavengers Prostaglandin Receptor COX AGS cells inhibit mucosal protection gastroduodenal ulcer Inhibitor OPC-12759 COX-2 gastric cancer Cyclooxygenase PGE2 Proamipide OPC12759 OPC 12759 gastritis inhibitor