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Rhapontigenin

Catalog No. T3776 CAS 500-65-2

Synonyms: Protigenin

Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).

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Rhapontigenin, CAS 500-65-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 184.00
25 mg	In stock	$ 357.00
50 mg	In stock	$ 537.00
100 mg	In stock	$ 672.00

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Purity: 99.88%

Purity: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).
Targets&IC50	HL-60R:48 μM, HepG2 cells:48 μM, CYP1A1:400 nM
Source	Natural Products > Polygonaceae > Rheum

Synonyms	Protigenin
Molecular Weight	258.27
Formula	C15H14O4
CAS No.	500-65-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 46 mg/mL(178.1 mM)

References and Literature

1. Jo SP1, Kim JK2, Lim YH1. Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet.Planta Med. 2014 Aug;80(13):1067-71. 2. Kim N1, Kim JK, Hwang D, Lim YH.The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans.Med Mycol. 2013 Jan;51(1):45-52. 3. Kim JS1, Kang CG, Kim SH, Lee EO. Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells.J Nat Prod. 2014 May 23;77(5):1135-9.

Citations

1. Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021：1781

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Infection Compound Library Antioxidant Compound Library Anti-Cardiovascular Disease Compound Library Anti-Tumor Natural Product Library Natural Product Library Anti-infective Natural Product Library Tibetan medicine Compound Library Target-Focused Phenotypic Screening Library Anti-Fibrosis Compound Library

Related Products

Related compounds with same targets

Clomethiazole YM 511 Topiroxostat Apigenin Clobetasol propionate LY 43578 Ginsenoside F1 (S)-(+)-N-3-Benzylnirvanol

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rhapontigenin 500-65-2 Metabolism Microbiology/Virology Antibacterial Antifungal P450 CYPs Fungal Inhibitor anticoagulative Protigenin antiangiogenic inhibit Bacterial purgative Cytochrome P450 antiallergic hypoglycemic inhibitor

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