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Ribostamycin sulfate

Catalog No. T1214 CAS 53797-35-6

Synonyms: Vistamycin sulfate

Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome.

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Ribostamycin sulfate, CAS 53797-35-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 31.00
25 mg	In stock	$ 48.00
50 mg	In stock	$ 65.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 155.00
500 mg	In stock	$ 262.00

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Purity: 99.72%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome.
In vitro	Compared to other antibiotics, Ribostamycin (400 mg/kg/day) exhibits the lowest ototoxicity and maintains lower drug concentrations in the inner ear fluid of guinea pigs. Ribostamycin demonstrates minimal ototoxicity to both the cochlea and vestibular apparatus in guinea pigs.
In vivo	Ribostamycin effectively inhibits aminoglycoside-modifying enzymes in gentamicin-resistant Pseudomonas aeruginosa without suppressing protein disulfide isomerase (PDI) activity, although it does inhibit its chaperone activity. At a 100:1 molar ratio with PDI, Ribostamycin nearly completely inhibits chaperone activity. The dissociation constant (KD) for Ribostamycin binding to immunogenic PDI is 0.319 mM. Additionally, Ribostamycin exhibits antibacterial activity against Borrelia burgdorferi with a minimum inhibitory concentration (MIC) of 18.7 mg/L. At a concentration of 16 mcg/mL, Ribostamycin inhibits P. stagnora, P. zopfii, and P. wickerhamii strains by 100%, 100%, and 95%, respectively.

Synonyms	Vistamycin sulfate
Molecular Weight	552.55
Formula	C17H34N4O10·H2SO4
CAS No.	53797-35-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Horibe T, et al. Biochem Biophys Res Commun, 2001, 289(5), 967-972. 2. Hunfeld KP, et al. Int J Antimicrob Agents, 2001, 17(3), 203-208. 3. Casal M, et al. Mycopathologia, 1983, 83(1), 21-23. 4. Kitasato I, et al. Chemotherapy, 1990, 36(2), 155-168.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Natural Product Library for HTS Natural Product Library Bioactive Compounds Library Max FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Anti-infective Natural Product Library Approved Drug Library

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Keywords

Ribostamycin sulfate 53797-35-6 Microbiology/Virology Antibacterial Antibiotic Inhibitor Vistamycin sulfate Vistamycin inhibit Vistamycin Sulfate Bacterial Ribostamycin Ribostamycin Sulfate inhibitor

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