Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 138.00 | |
2 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 317.00 | |
10 mg | In stock | $ 467.00 | |
25 mg | In stock | $ 768.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,450.00 | |
500 mg | In stock | $ 2,890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 386.00 |
Description | Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. |
Targets&IC50 | FKBP:(EC50)0.1 nM |
In vitro | AP1903, a bivalent 'dimerizer' drug that binds FKBP and induces Fas cross-linking.?A single 2-hour treatment eliminated approximately 80% of T cells, and multiple exposures induced further apoptosis.?T cells were eliminated regardless of their proliferation state, suggesting that the AP1903/Fas system, which contains only human components, is a promising alternative to HSV-tk for treating GVHD[2]. |
In vivo | Constitutive hGH secretion provides a convenient and accurate way to monitor the number of viable cells in vivo because hGH has a serum half-life of only ≈3 min in mice. Over 3 consecutive days, we implanted these cells i.m. into nude mice, and treated the animals i.v. with various doses of Rimiducid, and then determined serum hGH levels as a measure of the number of surviving cells. Rimiducid (AP1903; i.v.,0.01, 0.1, 1, 10, and 100 mg/kg) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg[1]. |
Molecular Weight | 1411.63 |
Formula | C78H98N4O20 |
CAS No. | 195514-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (35.42 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Rimiducid 195514-63-7 Apoptosis Metabolism Others Fatty Acid Synthase AP1903 Inhibitor FKBP AP-1903 AP 1903 inhibit FK506-binding protein inhibitor