Home Tools
Log in
Cart

Ro 20-1724

Catalog No. T19706   CAS 29925-17-5
Synonyms: Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone, Ro20-1724

Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ro 20-1724 Chemical Structure
Ro 20-1724, CAS 29925-17-5
Pack Size Availability Price/USD Quantity
2 mg 5 days $ 49.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.14%
Purity: 98.82%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM.
Targets&IC50 PDE4:2.0 μM, PDE4:3.1 μM(Ki)
In vivo RO-20-1724 was found to not only improve learning and memory in MWM and PA paradigms but also restore STZ induced elevation in cholinesterase activity. Further, RO-20-1724 significantly reduced malondialdehyde and nitrite levels, and restored the glutathione levels indicating attenuation of oxidative stress[2].
Synonyms Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone, Ro20-1724
Molecular Weight 278.35
Formula C15H22N2O3
CAS No. 29925-17-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/Ml(179.63 mM)

Ethanol: 50 mg/Ml(179.63 mM)

TargetMolReferences and Literature

1. Reeves ML, Leigh BK, England PJ. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem J. 1987 Jan 15;241(2):535-41. 2. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245. 3. Morrison MR, Hall CL, Pardue S, Brodeur R, Baskin F, Rosenberg RN. The synthesis and degradation of poly(a)-containing mRNAs in mouse neuroblastoma cells treated with dibutyryl cAMP or with Ro20-1724. J Neurochem. 1980 Jan;34(1):50-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Inhibitor Library ReFRAME Related Library Anti-Alzheimer's Disease Compound Library

Related Products

Related compounds with same targets
Torbafylline BC 11-38 ATX inhibitor 5 BW-A 78U Norbraylin Anagrelide hydrochloride Z-HA155 Ayanin

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ro 20-1724 29925-17-5 Metabolism PDE neuroprotective Ro 201724 Ro-20-1724 Ro 20-174 Ro 20 1724 phosphodiesterase cognitive cAMP antioxidant 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone inhibit Inhibitor Phosphodiesterase (PDE) Ro20-1724 inhibitor

 

TargetMol