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Ropivacaine hydrochloride monohydrate

Catalog No. T6645 CAS 132112-35-7

Synonyms: Ropivacaine HCl, Ropivacaine HCl monohydrate, LEA 103, LEA-103 HCl

Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

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Ropivacaine hydrochloride monohydrate Chemical Structure

Ropivacaine hydrochloride monohydrate, CAS 132112-35-7

Pack Size	Availability	Price/USD
10 mg	In stock	$ 32.00
25 mg	In stock	$ 48.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 98.00
200 mg	In stock	$ 155.00
500 mg	In stock	$ 262.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 100%

Purity: 99.80%

Biological Description

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Description	Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
Targets&IC50	TREK1 (COS-7 cell membrane):402.7 μM (IC50)
In vitro	Raltitrexed induces double-stranded DNA breaks in a concentration-dependent manner. In Lovo cells and LS174T cell lines containing wild-type p53, Raltitrexed increases the levels of the Bax protein up to 5-fold. In human colon cancer cells, Raltitrexed is actively absorbed into cells and is then rapidly and extensively metabolized into a series of polyglutamates, which results in the effective inhibition of thymidylate synthase. Raltitrexed is delivered to the brain very quickly and can be detected in all brain tissues within 5 minutes. In human colon cancer cells, the combination of Raltitrexed and SN-38 results in a synergistic cytotoxic effect within a range of concentrations. Raltitrexed is a specific folate-based inhibitor of thymidylate synthase. The effect on the activity of advanced rectal cancer is similar to fluorouracil (5-fluorouracil) plus leucovorin. Raltitrexed produces activity by rapid cell entry and glutamination. The glutaminated derivatives are more than 100 times more active than the parent compound. In the HCT-8 cell line, Raltitrexed results in an increase in intracellular phosphoribosyl pyrophosphate (PRPD) indicating that the cytotoxic effect of Raltitrexed in combination with 5-FU is due to increased nucleotide formation of 5-FU. Combinations of Raltitrexed and folinic acid (5FU-FA) show a combination of mode-dependent, synergistic inhibition of proliferation, which is determined by measuring the combination series. Raltitrexed combined with Vorinostat produced significant synergistic effects of cell cycle perturbation and S-phase arrest.

Synonyms	Ropivacaine HCl, Ropivacaine HCl monohydrate, LEA 103, LEA-103 HCl
Molecular Weight	328.88
Formula	C17H29ClN2O2
CAS No.	132112-35-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 62 mg/mL (199.44 mM)

H2O: 46 mg/mL (147.97 mM)

References and Literature

1. Simpson D, et al. Drugs, 2005, 65(18), 2675-2717.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Bioactive Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Preclinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Ropivacaine hydrochloride monohydrate 132112-35-7 Membrane transporter/Ion channel Sodium Channel Potassium Channel LEA-103 hypertension Ropivacaine HCl Ropivacaine HCl monohydrate Na channels pain K(2P) neuropathic Inhibitor vasoconstrictive KcsA Ropivacaine hydrochloride Monohydrate Na+ channels Ropivacaine HCl Monohydrate potassium Ropivacaine Hydrochloride TREK-1 inhibit conduction LEA 103 Ropivacaine hydrochloride LEA103 channel neuronal LEA-103 HCl inhibitor

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