store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 33.00 | |
50 mg | In stock | $ 45.00 | |
100 mg | In stock | $ 62.00 | |
200 mg | In stock | $ 88.00 | |
500 mg | In stock | $ 143.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
Targets&IC50 | PPARγ2:100 nM (EC50), PPARγ1:30 nM (EC50) |
In vitro | Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. [1] In Bcr-Abl+ leukemia cell lines, Bafetinib induces both caspase-mediated and caspase-independent cell death by blocking the phosphorylation of Bcr-Abl. [2] |
Synonyms | BRL-49653 HCl, Rosiglitazone HCl |
Molecular Weight | 393.89 |
Formula | C18H19N3O3S·HCl |
CAS No. | 302543-62-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 73 mg/mL (185.3 mM)
DMSO: 73 mg/mL (185.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Rosiglitazone hydrochloride 302543-62-0 Apoptosis Autophagy DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Ferroptosis TRP/TRPV Channel PPAR mellitus hepatocellular antihyperglycemic Inhibitor cancer senescence Rosiglitazone PPARγ BRL-49653 HCC diabetic carcinoma BRL49653 bladder BRL-49653 HCl neuroprotection BRL 49653 Rosiglitazone Hydrochloride diabetes TRP Channel ovarian cancer smoke Rosiglitazone HCl inhibit Transient receptor potential channels Peroxisome proliferator-activated receptors inhibitor