Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 396.00 | |
25 mg | In stock | $ 648.00 | |
50 mg | In stock | $ 912.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects. |
In vitro | In MOLT-4 but not Jurkat cells, Rosiptor (0.1-10 μM, 30 minutes) inhibits Akt activation [1]. |
In vivo | Rosiptor (10 mg/kg, p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability [1]. Rosiptor (3-30 mg/kg, p.o., daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity [2]. |
Cell Research | Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation) [1]. Concentration: 0.1, 1, 10 μM. Incubation Time: 30 minutes |
Animal Research | Animal Model: 6-8 weeks old male CD-1 mice[1]. Dosage: 3, 10, 30 mg/kg. Administration: p.o., daily for 3 days |
Synonyms | AQX-1125 |
Molecular Weight | 321.5 |
Formula | C20H35NO2 |
CAS No. | 782487-28-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 145 mg/mL (451 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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Rosiptor 782487-28-9 Metabolism Phosphatase AQX1125 AQX-1125 Inhibitor AQX 1125 inhibit inhibitor