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Rosiptor

Catalog No. TQ0032   CAS 782487-28-9
Synonyms: AQX-1125

Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.

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Rosiptor Chemical Structure
Rosiptor, CAS 782487-28-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 113.00
5 mg In stock $ 289.00
10 mg In stock $ 396.00
25 mg In stock $ 648.00
50 mg In stock $ 912.00
1 mL * 10 mM (in DMSO) In stock $ 318.00
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Purity: 99.53%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
In vitro In MOLT-4 but not Jurkat cells, Rosiptor (0.1-10 μM, 30 minutes) inhibits Akt activation [1].
In vivo Rosiptor (10 mg/kg, p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability [1]. Rosiptor (3-30 mg/kg, p.o., daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity [2].
Cell Research Cell Line: MOLT-4 cells and SHIP1-deficient Jurkat cells (IGF-1 stimulation) [1]. Concentration: 0.1, 1, 10 μM. Incubation Time: 30 minutes
Animal Research Animal Model: 6-8 weeks old male CD-1 mice[1]. Dosage: 3, 10, 30 mg/kg. Administration: p.o., daily for 3 days
Synonyms AQX-1125
Molecular Weight 321.5
Formula C20H35NO2
CAS No. 782487-28-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 145 mg/mL (451 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Stenton GR, et al. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol. 2013 Mar;168(6):1506-18. 2. Cross J, et al. AQX-1125, small molecule SHIP1 activator inhibits NSC-125066-induced pulmonary fibrosis. Br J Pharmacol. 2017 Sep;174(18):3045-3057.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library NO PAINS Compound Library Orally Active Compound Library Glycometabolism Compound Library Anti-Metabolism Disease Compound Library Phosphatase Inhibitor Library ReFRAME Related Library Clinical Compound Library

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Keywords

Rosiptor 782487-28-9 Metabolism Phosphatase AQX1125 AQX-1125 Inhibitor AQX 1125 inhibit inhibitor

 

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