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Rosmanol

Catalog No. T7033 CAS 80225-53-2

Rosmanol has Antioxidant activity, it can activate the Antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces Apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.

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Rosmanol, CAS 80225-53-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.

Molecular Weight	346.42
Formula	C20H26O5
CAS No.	80225-53-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Chloroform: Soluble

DMSO: 60 mg/ml (173.2 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis [J]. J Pharm Pharm Sci. 2015;18(4):448-59. 2. Petiwala S M, Johnson J J. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity[J]. Cancer Letters, 2015, 367(2):93-102. 3. Fischedick J T. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the antioxidant response element[J]. Bioorganic & Medicinal Chemistry, 2013, 21(9):2618-2622.

Citations

1. Li T, Lu D, Yao C, et al. Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nature Communications. 2022, 13(1): 1-16.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Rosmanol 80225-53-2 Immunology/Inflammation Neuroscience oxidation-reduction Antioxidant COX Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.