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Rotigaptide TFA(355151-12-1 free base)

Catalog No. T16790L CAS T16790L

Synonyms: Rotigaptide TFA

Rotigaptide TFA(355151-12-1 free base) is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide TFA(355151-12-1 free base) prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.

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Rotigaptide TFA(355151-12-1 free base) Chemical Structure

Rotigaptide TFA(355151-12-1 free base), CAS T16790L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 398.00
10 mg	In stock	$ 598.00
25 mg	In stock	$ 956.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 565.00

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Purity: 99.21%

Biological Description

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Storage & Solubility Information

Description	Rotigaptide TFA(355151-12-1 free base) is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide TFA(355151-12-1 free base) prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.
In vitro	Rotigaptide TFA (100 nM; 24 hours) does not affect INS-1 cell apoptosis itself. Rotigaptide (100 nM; 24 hours) has a positive effect on the cycloheximide-mediated decrease in Cx43 protein levels in cultured neonatal ventricular myocytes. And it obviously decreases apoptosis in cytokine-exposed cells ~10% at IL-1b concentrations above 15 pg/ml in rat insulin-producing INS-1 cells [1][2].
In vivo	Rotigaptide TFA (intravenous administration; 300 mg/kg; single dose) treatment in mice and rats does not cause toxicity in either species. Rotigaptide (continuous intravenous infusion; 5-14 days) in rats (100 mg/kg) and dogs (10 mg/kg) is well tolerated and produces no compound-related effects or histological toxicological findings in escalating dose studies [3].

Synonyms	Rotigaptide TFA
Molecular Weight	731.67
Formula	C30H40F3N7O11
CAS No.	T16790L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.32 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Ghiasi SM, Hansen JB, Christensen DP, Tyrberg B, Mandrup-Poulsen T. The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets. Int J Mol Sci. 2020;21(12):4311. Published 2020 Jun 17. doi:10.3390/ijms21124311 2. Stahlhut M, Petersen JS, Hennan JK, Ramirez MT. The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes. Cell Commun Adhes. 2006;13(1-2):21-27. doi:10.1080/15419060600631375 3. Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library NO PAINS Compound Library

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Keywords

Rotigaptide TFA(355151-12-1 free base) T16790L Cytoskeletal Signaling Gap Junction Protein Rotigaptide TFA(355151 12 1 free base) Rotigaptide TFA Rotigaptide TFA(355151121 free base) inhibitor inhibit

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