Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 33.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 94.00 | |
50 mg | In stock | $ 153.00 | |
100 mg | In stock | $ 276.00 | |
200 mg | In stock | $ 412.00 | |
500 mg | In stock | $ 673.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. |
In vitro | Rufinamide effectively suppresses maximal electroshock (MES)-induced tonic convulsions in mice (ED50 = 23.9 mg/kg) and rats (ED50 = 6.1 mg/kg). Additionally, Rufinamide inhibits pentylenetetrazol-(ED 50=54.0), bicuculline-(ED 50=50.5), and picrotoxin (ED 50=76.3 mg/kg) provoked clonic seizures in mice. Furthermore, it prevents pentylenetetrazole-induced epileptic seizures in mice at an effective dose of 45.8 mg/kg (ED50). |
In vivo | Rufinamide inhibits sodium-dependent action potentials in neurons, potentially exhibiting membrane stabilizing effects. |
Synonyms | CGP 33101, E 2080, RUF 331 |
Molecular Weight | 238.19 |
Formula | C10H8F2N4O |
CAS No. | 106308-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 47 mg/mL (197.32 mM), warmed
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Rufinamide 106308-44-5 Membrane transporter/Ion channel Sodium Channel Inhibitor CGP33101 CGP-33101 RUF-331 RUF331 CGP 33101 E 2080 E2080 inhibit RUF 331 E-2080 inhibitor