Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 |
Description | S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (IC50s: 11 nM and 27 μM for COX-2 and COX-1 in human intact cells). |
Targets&IC50 | COX-2:11 nM, COX-1:27 μM, 5-LOX: |
In vitro | S-2474 inhibits the PGD2 generation in a concentration-dependent manner (IC50=69.8±21.9?nM). S-2474 also shows neuroprotective effects in the Aβ(1-40)-induced neuronal cell death. S-2474 prevents neurons from Aβ-induced cell death significantly in a concentration-dependent manner (IC50 =26±12?nM). S-2474 significantly prevents neurons from undergoing sPLA2-IIA-induced cell death. S-2474 completely ameliorates sPLA2-IIA-induced apoptotic features such as the condensation of chromatin and the fragmentation of DNA. S-2474 significantly inhibits the sPLA2-IIA-induced generation of PGD2. S-2474 inhibits sPLA2-IIA-induced neuronal cell death in a concentration-dependent manner (IC50 = 94 nM). S-2474 (10?μM) completely inhibits Aβ(25-35)-induced neuronal cell death. S-2474 (10?μM) lowers the elevated level of PGD2 significantly and reduces radicals from Aβ(25-35)-treated neurons [1][2]. |
Molecular Weight | 365.53 |
Formula | C20H31NO3S |
CAS No. | 158089-95-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S-2474 158089-95-3 Immunology/Inflammation Neuroscience COX S 2474 S2474 inhibitor inhibit