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S18-000003

Catalog No. T16832 CAS 2068119-11-7

S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.

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S18-000003, CAS 2068119-11-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 842.00
100 mg	In stock	$ 1,160.00
500 mg	In stock	$ 2,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 243.00

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Purity: 99.91%

Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.
Targets&IC50	RORγt:29 nM

Molecular Weight	518.55
Formula	C26H25F3N2O4S
CAS No.	2068119-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

References and Literature

1. Sasaki Y, et al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Lipid Metabolism Compound Library Bioactive Compound Library Transcription Factor-Targeted Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Kinase Inhibitor Library Nuclear Receptor Compound Library Target-Focused Phenotypic Screening Library

Related Products

Related compounds with same targets

TAK-828F RORγt inverse agonist 14 GSK805 Melatonin SR1001 Zymostenol AZD-0284 TMP920

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

S18-000003 2068119-11-7 Metabolism ROR orphan aberrations acid psoriasis Inhibitor RAR-related orphan receptor retinoic receptor-related S18 000003 S-18-000003 RORγt thymic inhibit S18000003 inhibitor

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