Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 289.00 | |
50 mg | In stock | $ 396.00 | |
100 mg | In stock | $ 593.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 113.00 |
Description | SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. |
In vitro | SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. |
In vivo | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
Animal Research | Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference) |
Synonyms | Smoothened Agonist HCl |
Molecular Weight | 526.52 |
Formula | C28H29Cl2N3OS |
CAS No. | 2095432-58-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 38 mg/mL (72.2 mM)
DMSO: 66 mg/mL (125.4 mM)
You can also refer to dose conversion for different animals. More
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SAG hydrochloride (912545-86-9(free base)) 2095432-58-7 GPCR/G Protein Stem Cells Hedgehog/Smoothened SAG hydrochloride (912545 86 9(free base)) Smoothened Agonist HCl SAG hydrochloride (912545869(free base)) inhibitor inhibit