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Sangivamycin

Catalog No. T9605 CAS 18417-89-5

Synonyms: cells, Nucleoside Antimetabolite/Analog, Sangivamycin, antitumor, NSC-65346, PKC, MCF7, NSC65346, BA 90912, Inhibitor, Protein kinase C, NSC 65346, nucleoside, inhibit, analog, BA90912, BA-90912, antiproliferative

Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.

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Sangivamycin, CAS 18417-89-5

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Purity: 98%

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Description	Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
Targets&IC50	PKC:10 μM(Ki)
In vitro	Sangivamycin (0.3 μM; 0-72 hours) exhibits almost maximal cytocidal for MCF7/ADR or cytostatic for MCF7/WT effects. Sangivamycin activates caspases in MCF7/ADR cells. Upon exposure of MCF7/ADR cells to Sangivamycin (0.3 μM), a vast amount of cleavage of lamin A to a 28-kDa fragment is detected within 48 hours. Sangivamycin has differential antitumor effects in drug-sensitive MCF7/wild type (WT) cells, causing growth arrest, and in multidrug-resistant MCF7/adriamycin-resistant (ADR) human breast carcinoma cells, causing massive apoptotic cell death[2].

Synonyms	cells, Nucleoside Antimetabolite/Analog, Sangivamycin, antitumor, NSC-65346, PKC, MCF7, NSC65346, BA 90912, Inhibitor, Protein kinase C, NSC 65346, nucleoside, inhibit, analog, BA90912, BA-90912, antiproliferative
Molecular Weight	309.28
Formula	C12H15N5O5
CAS No.	18417-89-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 95 mg/mL (307.17 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Lee SA, et al. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. J Biol Chem. 2007;282(20):15271-15283. 2. Loomis CR, Bell RM. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C. J Biol Chem. 1988;263(4):1682-1692.

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