store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 115.00 | |
25 mg | In stock | $ 238.00 | |
50 mg | In stock | $ 362.00 | |
100 mg | In stock | $ 543.00 | |
200 mg | In stock | $ 653.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. |
Targets&IC50 | VEGFR3:23 nM |
In vitro | KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. It inhibits DNA-PK and PI-3K with greater potency in MCF7 than SW620 cell using cell-based assays. Five-day exposure to 1 mM KU-0060648 inhibits cell proliferation by more than 95% in MCF7 cells but only by 55% in SW620 cells. In clonogenic survival assays, KU-0060648 increases the cytotoxicity of etoposide and doxorubicin across the panel of DNA-PKcs-proficient cells, but not in DNA-PKcs-deficient cells, confirming that enhanced cytotoxicity of the topoisomerase II poisons etoposide and doxorubicin is due to DNA-PK inhibition. [1] |
Synonyms | SAR 131675 |
Molecular Weight | 358.39 |
Formula | C18H22N4O4 |
CAS No. | 1433953-83-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 16.67 mg/mL (46.51 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SAR131675 1433953-83-3 Angiogenesis Tyrosine Kinase/Adaptors VEGFR SAR 131675 Inhibitor Vascular endothelial growth factor receptor SAR-131675 inhibit inhibitor