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SB228357

Catalog No. T16856 CAS 181629-93-6

SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.

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SB228357, CAS 181629-93-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.
Targets&IC50	5-HT2B Receptor:8 （pki）, 5-HT2A Receptor:6.9 （pki）, 5-HT2C Receptor:9 （pki）
In vivo	In male Sprague Dawley rats, oral administration of SB228357 (0-10 mg/kg) reverses Haloperidol-induced catalepsy obviously[2].

Molecular Weight	431.391
Formula	C22H17F4N3O2
CAS No.	181629-93-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 38.9 mg/mL (90.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bromidge SM, et al. Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. 2. Reavill C, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4.

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Keywords

SB228357 181629-93-6 G蛋白偶联受体神经科学 5-HT Receptor SB-228357 Inhibitor inhibitor inhibit

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