Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 493.00 | |
100 mg | In stock | $ 723.00 |
Description | SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor. |
In vitro | 57461A is a potent competitive inhibitor of recombinant human LTA(4) hydrolase when either LTA(4) (IC(50) = 2.5 nM, K(i) = 23 nM) or peptide substrates (IC(50) = 27 nM) are used.?In human whole blood, the IC(50) for calcium ionophore-induced LTB(4) production was 49 nM, indicative of good cell penetration.?Whole blood production of the cyclooxygenase metabolite thromboxane B(2) was not affected.?SC-57461A was also active in several other species, including mouse, rat, dog, and rhesus monkey.?The data indicate that SC-57461A is a potent and selective inhibitor of LTA(4) hydrolase[2]. |
Molecular Weight | 363.9 |
Formula | C20H26ClNO3 |
CAS No. | 423169-68-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.4 mg/mL
You can also refer to dose conversion for different animals. More
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SC-57461A 423169-68-0 Metabolism Aminopeptidase inhibit SC57461A SC 57461A Leukotriene A4 Inhibitor orally active LTA4 hydrolase inhibitor