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SC75741

Catalog No. T6661 CAS 913822-46-5

SC75741 is a potent P65 inhibitor with IC50 of 200 nM

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SC75741, CAS 913822-46-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 139.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 478.00
100 mg	In stock	$ 689.00
500 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SC75741 is a potent P65 inhibitor with IC50 of 200 nM
Targets&IC50	NF-κB:200 nM(EC50)
In vitro	SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM. [1] SC75741 inhibits replication of influenza A and B viruses by inhibiting NF-κB-mediated signalling on a transcriptional level. Moreover, SC75741 shows a high barrier for development of resistant virus variants. [2]
In vivo	SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection. [2]
Kinase Assay	NF-κB reporter gene assay: The NF-κB reporter gene assay is prepared with A549-NF-κB-SEAP cell line according to manufacturer's instructions. In short, A549 cells stably transfected with pNF-κB-SEAP reporter gene plasmid are plated and allowed to attach overnight. The cells are subsequently incubated for 5 h with described compounds at 100, 30, 10, 3, 1, 0.3, 0.1, and 0 μM and then stimulated with 10 ng/ml TNF-α for 22 h. The supernatant of the cell is analyzed for SEAP activity using a chemiluminescent SEAP reporter gene assay.
Cell Research	Cell viability assay is prepared using a CellTiter-BluTM Cell Viability Assay. For each concentration of the compound four replicates are measured.(Only for Reference)

Molecular Weight	565.67
Formula	C29H23N7O2S2
CAS No.	913822-46-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 33 mg/mL (58.3 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Leban J, et al. Bioorg Med Chem Lett. 2007, 17(21), 5858-5862. 2. Ehrhardt C, et al. Cell Microbiol. 2013, 15(7), 1198-1211. 3. Hu, Qiuhui, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata, and Wenjian Yang. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii [J]. Food Funct. 2018 Jul 17;9(7):3764-3775.

Citations

1. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. 2. Hu Q, Du H, Ma G, et al. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food & Function. 2018, 9(7): 3764-3775 3. Su J, Yin W, Huo M, et al.Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways.Naunyn-Schmiedeberg's Archives of Pharmacology.2023: 1-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Infection Compound Library Antioxidant Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Viral Compound Library Anti-Pancreatic Cancer Compound Library Oxidation-Reduction Compound Library Anti-Prostate Cancer Compound Library

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Keywords

SC75741 913822-46-5 Microbiology/Virology NF-Κb NF-κB Influenza Virus SC-75741 inhibit Inhibitor Nuclear factor-kappaB SC 75741 Nuclear factor-κB inhibitor

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